Failed colony in North America (1584–1590)
Source (Wikipedia): Roanoke Colony

The Roanoke Colony was an attempt by Sir Walter Raleigh to found the first permanent English settlement in North America. The colony was founded in 1585, but when it was visited by a ship in 1590, the colonists had inexplicably disappeared. It has come to be known as the Lost Colony, and the fate of the 112 to 121 colonists remains unknown.